Arimisim 1mg which active substance is anastrozole is an aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women |   .jpg) |
Overview
Arimisim 1mg
* Active substance: anastrazole
* Bioavailability: 83-85%
* Half-life: 48.8h
* Metabolism: 85% hepatic
* Protein binding: 40%
* Bioavailability: 83-85%
* Half-life: 48.8h
* Metabolism: 85% hepatic
* Protein binding: 40%
Arimisim 1mg which active substance is anastrozole is an aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women.
The severity of breast cancer is increased by estrogen, as sex hormone cause hyperplastia, and differentiation at estrogen receptor sites. Arimisim 1mg (anastrazole) works by inhibiting the synthesis of estrogen. Anastrazole binds reversibly to the aromatase enzyme trough competitive inhibition, inhibits the converson of androgens to estrogens in peripheral tissue outside the Central Nervous System and a few CNS sites in various regions within the brain.
Anastrazole has been tested for reducing estrogens including estradiol in men. Excess estradiol in men can cause benign prostatic hyperplastia, gynecomastia and symptoms of hypogonadism. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargment and prostate cancer. Some athletes and body builders will also use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogens; gynecomastia and water retention.
Study data suggests dosages of 0.5mg to 1mg a day reduce serum estradiol approx. 50% in men, which differs in postmenopausal woman.
Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia. Following the onset of puberty, the epiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system. It is shown to help slow this process and increase adult height prediction in adolescent males treated with protein-based peptide hormones for the treatment of growth hormone deficiency.
Security
Each Arimisim 1mg bottle contains a security hologram applied to the metalic bottle itself. On the transparent box in which all NOVOCRINE orals come in are applied two hologram, one on the bottom which is round and written with the brand name and one on the top of the box that is a tamper evident hologram that reveals if the product has been open before supplied or if is sealed.
